Processes to separate enantiomers
In the pharmaceutical, fine chemical, food and agrochemical industries, due to the homochirality of life, there is a large interest in producing pure enantiomers. This is a challenging task since highly enantioselective synthesis methods are difficult to develop. Conventional chemical synthesis is non-selective and leads to 50:50 (racemic) mixtures, creating a need in efficient enantioselective separation processes. Chromatography and crystallization are currently the most powerful methods. Recently it could be demonstrated, that an optimized joint application of these two methods can provide efficient overall processes.
The lecture will first introduce essential thermodynamic properties required for a rational development of enantioselective separation processes, in particular the different types of phase diagrams of chiral compounds. Since the occurence of conglomerates is very limited and most frequently racemic compounds are formed, successful crystallization processes require enriched feed solutions. This enrichment can be provided either by a partially selective synthesis or by a suitable first separation process.
The presentation will describe several case studies devoted to design and apply preparative chromatography in combination with subsequent selective crystallization. The possibility to directly combine continuously performed synthesis reactions and separation processes as well as the incorporation of racemizing the counter-enantiomer within yield increasing recycling concepts will be also discussed. Several of these aspects will be in the next four years intensively investigated within the Horizon2020 Innovative Training Network “Continuous resolution and deracemization of chiral components by crystallization (CORE)”.
Date: Thursday 2 February 2017
Time: 09:00 – 10:00 hrs
Location: CW507a and b, Cathedral Wing Business School, University of Strathclyde
Book your place online at https://www.eventbrite.co.uk/e/core-network-lecture-by-professor-andreas-seidel-morgenstern-tickets-30523980046
You may also be interested in the CORE Network Lecture by Professor Marco Mazzotti - Crystal Shape Engineering https://t.co/oBzspOF5L4