201702FEB

CORE Network Lecture by Professor Andreas Seidel-Morgenstern, Otto von Guericke University and Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Processes to separate enantiomers

Abstract

In the pharmaceutical, fine chemical, food and agrochemical industries, due to the homochirality of life, there is a large interest in producing pure enantiomers. This is a challenging task since highly enantioselective synthesis methods are difficult to develop. Conventional chemical synthesis is non-selective and leads to 50:50 (racemic) mixtures, creating a need in efficient enantioselective separation processes. Chromatography and crystallization are currently the most powerful methods. Recently it could be demonstrated, that an optimized joint application of these two methods can provide efficient overall processes.
 
The lecture will first introduce essential thermodynamic properties required for a rational development of enantioselective separation processes, in particular the different types of phase diagrams of chiral compounds. Since the occurence of conglomerates is very limited and most frequently racemic compounds are formed, successful crystallization processes require enriched feed solutions. This enrichment can be provided either by a partially selective synthesis or by a suitable first separation process.
 
The presentation will describe several case studies devoted to design and apply preparative chromatography in combination with subsequent selective crystallization. The possibility to directly combine continuously performed synthesis reactions and separation processes as well as the incorporation of racemizing the counter-enantiomer within yield increasing recycling concepts will be also discussed. Several of these aspects will be in the next four years intensively investigated within the Horizon2020 Innovative Training Network “Continuous resolution and deracemization of chiral components by crystallization (CORE)”.
 

Date:                   Thursday 2 February 2017
Time:                   09:00 – 10:00 hrs
Location:             CW507a and b, Cathedral Wing Business School, University of Strathclyde

 

Book your place online at https://www.eventbrite.co.uk/e/core-network-lecture-by-professor-andreas-seidel-morgenstern-tickets-30523980046

 

You may also be interested in the CORE Network Lecture by Professor Marco Mazzotti - Crystal Shape Engineering https://t.co/oBzspOF5L4   


Events

CORE Workshop - Solid State Properties
The first CORE Workshop on Solid State Properties will take place on 6 - 10 November 2017, Cluj-Napoca, Romania..... more

CORE ITN Day at Summer School
7 July 2017
Radboud University, Nijmegen, The Netherlands
This event is for CORE ITN members only..... more

ITN CORE and EFCE Summer School on Chiral Crystallisation, Resolution & Deracemization
3 6 July 2017 (followed by CORE ITN day on 7 July)
Radboud University, Nijmegen, The Netherlands
The goal of this summer school is to outline the basics of chirality, crystallisation, resolution and deracemization. .... more

CORE Network Lecture by Professor Andreas Seidel-Morgenstern, Otto von Guericke University and Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
In the pharmaceutical, fine chemical, food and agrochemical industries, due to the homochirality of life, there is a large interest in producing pure enantiomers. This is a challenging task since highly enantioselective synthesis methods are difficult to develop. Conventional chemical synthesis is non-selective and leads to 50:50 (racemic) mixtures, creating a need in efficient enantioselective separation processes. Chromatography and crystallization are currently the most powerful methods. Recently it could be demonstrated, that an optimized joint application of these two methods can provide efficient overall processes..... more

CORE Network Lecture by Professor Marco Mazzotti, ETH Zurich (Swiss Federal Institute of Technology in Zurich), Switzerland
The importance of crystallization in the pharmaceutical, food and fine chemical industries stems from its ability to yield highly pure solid products. Beside the final chemical purity, however, the solid state form, the size and the shape of the resulting particles are of paramount importance for the product quality, because they determine characteristics such as filterability, tabletability, flowability and even bioavailability. Practitioners in these industries are well aware of the fact that crystals can take on a variety of shapes, even for the same chemical substance. Any form of control over particle size and especially shape should allow for the design of improved processes..... more